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Jan 2, - The efficacy of male condom use in preventing herpes simplex virus-2 transmission among HIV-1 and herpes simplex virus-2 serodiscordant. Always use condoms and dental dams during oral, anal, and vaginal sex. Talk with your doctor about taking herpes medication every day, which can lower your chances of spreading herpes. Don't have sex during a herpes outbreak, even with a condom. There may be sores on places the condom doesn't cover.